Important Facts About Pelger-Huët Anomaly In Cats That You Need To Know


Pelger-Huët anomaly in cats is actually an inherited feline condition, wherein the neutrophils become hyposegmented. For instance, the nucleus of the cells has only two lobes or even has no lobes at all. For most of the parts, this is a bland condition that affects the domestic shorthair cats. In this article, we will be discussing what Pelger-Huët anomaly in cats really is. Read on to learn more!

Pelger-Huët Anomaly in Cats: What is this feline condition?

The Pelger-Huët Anomaly in cats is actually an unusual genetic condition, which affects the white blood cells in the cat’s body. Furthermore, this defect may cause the cells to have a strange structure and shape in comparison to the normal and healthy cells. Moreover, the method of bequest is believed to be not sex-related and dominant. This just means that the cats retaining just one copy of the Pelger-Huët Anomaly gene might have the condition. In the cats, thus far only the domestic shorthair cat breeds have been found to have this condition.

Causes of Pelger-Huët Anomaly

The Pelger-Huët Anomaly in cats is due to the transmitting of a faulty gene, which comes from the parent. This gene goes to the offspring kitten. In addition, in cats that are affected with this ailment, the genetic defect may cause the white blood cells to get dumbbell or bilobe in shape. The whole white blood cell count might just be normal, with just the appearance of the cells’ shape being the ones different.

Types and Symptoms of Pelger-Huët Anomaly

There are actually two different types of Pelger-Huët Anomaly in cats: homozygous and heterozygous. Heterozygous anomaly isn’t associated with an immunodeficiency, with predilection to infection, or with leukocyte function abnormalities. On the other hand, the heterozygous version is way more common and is known as the cat’s mature neutrophils look like metamyelocytes and bands. Contrariwise, the homozygous anomaly is commmonly lethal in the utero. Additionally, cats, which survive might have leukocytes that has oval to round nuclei on a tainted blood smear.


The homozygous Pelger-Huët Anomaly in cats occurs when the cat inherits 2 copies of the gene affected. For this to occur, both the father and mother may have had to have a copy, in order to pass on to the offspring. When the symptoms occur, it is commonly in circumstances of the homozygous Pelger-Huët Anomaly.


When the cat accedes to just one copy of the faulty gene from either its parents, this is known as heterozygous Pelger-Huët Anomaly in cats. In this form, most of the cats may not show any symptoms of the condition.

Moreover, the skeletal abnormalities, as well as the abnormal development of the cartilage were conveyed in a stillborn homozygous kitten. However, an unswerving link with the Pelger-Huët anomaly hasn’t been confirmed conclusively.

Prognosis of Pelger-Huët Anomaly

Due to the fact that most of the affected cats will not display any indications of the malady, Pelger-Huët Anomaly in cats is commonly detected as a part of an investigation of some other condition. In erratic cases wherein a reduced immune response is detected, the prognosis may be part of the normal evaluation of the makeup of the white blood cell of the blood of the cat. Mreoover, the prognosis may also be made as a part of an investigation of the increased rate of the birth mortality either in a multiple or a single litter/s by the cats used in the breeding programs. Further, the definitive prognosis of the condition may need the vet to gather a blood sample.

This may involve a fast and painless process, wherein the vet will insert a needle in the cat’s vein as well as withdraw a small blood sample. Either the vet or the lab will examine the blood under the microscope. The distorted qualities of white blood cells may commonly be freely identifiable. If this illness is alleged, you must attempt to give the vet with a blood sample from the mother of the cat, as well as the father.

This will help in providing a conclusive prognosis, as well as help in determining which parent owns the defective gene. In some instances of Pseudo Pelger-Huët Anomaly in cats, the shape of the white blood cells in the cat’s blood might change shape temporarily. This is caused by a primary bacterial infection or some circumstances of FeLV. Furthermore, the vet will also be able to extricate these conditions through the presence of some other symptoms not commonly found in the Pelger-Huët Anomaly in cats, as well as thru the use of more diagnostic blood tests.

Treatment for Pelger-Huët Anomaly

In most of the cats, diagnosis for the long-term management of the Pelger-Huët Anomaly in cats is good. If the cat is asymptomatic, it’ll have a great quality, as well as length of life and will show zero indications of the condition. In the cats that are considered for use in various breeding programs, you must speak to the vet about the modes of inheritance. A qualified vet in the reproductive issues might be capable of helping you in determining the proper use of the cat affected in any of the breeding programs. In a lot of instances, it might also be advisable to neuter or spay the affected cat, hence eliminating the likelihood for spread of the deficiency to the future generations.


Please enter your comment!
Please enter your name here